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NEUROLOGY 2006;66:592-594
© 2006 American Academy of Neurology
Brief Communications

Speech arrest with stimulation may not reliably predict language deficit after epilepsy surgery

M. Seeck, MD, A. J. Pegna, PhD, S. Ortigue, PhD, L. Spinelli, PhD, C. A. Dessibourg, MD, J. Delavelle, MD, O. Blanke, MD, C. M. Michel, PhD, T. Landis, MD and J. -G. Villemure, MD

From the Presurgical Epilepsy Evaluation Unit, "Functional Neurology and Neurosurgery Program" of the Universities of Geneva and Lausanne (M.S., L.S., C.A.D., O.B.), Departments of Neurology (A.J.P., S.O., C.M.M., T.L.) and Radiology (J.D.), University Hospital of Geneva; and the Department of Neurosurgery (J.-G.V.), University Hospital of Lausanne, SwitzerlandD. is also affiliated with the Institute Pédagogie Curative, University of Fribourg, Switzerland.

Address correspondence and reprint requests to Dr. Margitta Seeck, Department of Neurology, Hôpital Cantonal Universitaire de Genève, 24 rue Micheli-du-Crest, CH-1211 Genève 14, Switzerland; e-mail:margitta.seeck{at}hcuge.ch

The authors present a patient in whom electrical cortical stimulation of the posterior temporal cortex induced speech arrest, comprehension deficits, and other language-related impairments. This area was ultimately resected because of persistence of a severe seizure disorder. No postoperative aphasia was observed despite the cortical stimulation results, and the patient is since seizure free. These findings question the well-established principle that corticography directly reflects local cortical functions in all patients.

Supported by SNF grants (nos. 3200B0-104146, 3200-068105).

Disclosure: The authors report no conflicts of interest.

Received March 17, 2005. Accepted in final form November 1, 2005.






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