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NEUROLOGY 2004;63:1124-1126
© 2004 American Academy of Neurology
Brief Communications

Effectiveness of vagus nerve stimulation in epilepsy patients

A 12-year observation

B. M. Uthman, MD, A. M. Reichl, MD, J. C. Dean, MD, S. Eisenschenk, MD, R. Gilmore, MD, S. Reid, MD, S. N. Roper, MD and B. J. Wilder, MD

From the Neurology Service (Drs. Uthman, Reichl, and Wilder), Malcom Randall Department of Veterans Affairs Medical Center, and Departments of Neurology (Drs. Uthman, Eisenschenk, Gilmore, and Wilder), Neurosurgery (Drs. Reid and Roper), and Neuroscience (Dr. Uthman), University of Florida College of Medicine, Gainesville, and Department of Neurology (Dr. Dean), Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC.

Address correspondence and reprint requests to Dr. B.M. Uthman, Department of Neurology and Neuroscience, University of Florida College of Medicine and McKnight Brain Institute, Neurology Service (127), Malcom Randall VA Medical Center, 1601 SW Archer Rd., Gainesville, FL 32608; e-mail: basim.uthman{at}med.va.gov

A retrospective review of the safety, tolerability, and efficacy of vagus nerve stimulation (VNS) in 48 patients with intractable partial epilepsy was performed. Side effects were few and mild to moderate. Mean seizure frequency decreased by 26% after 1 year, 30% after 5 years, and 52% after 12 years with VNS treatment.

Received October 31, 2003. Accepted in final form May 10, 2004.

Drs. Uthman and Wilder have served as consultants to Cyberonics, Inc. Drs. Uthman and Roper have received grants from Cyberonics, Inc. (Dr. Uthman in excess of $10,000). Drs. Dean, Reid, Uthman, and Wilder have received honoraria from Cyberonics, Inc.

Presented in part at the 25th International Epilepsy Congress in Lisbon, Portugal, in October 2003 and published as an abstract in Epilepsia in September 2003.




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